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Related Experiment Video

Updated: Sep 3, 2025

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
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Caspase 8 Expression Patterns in Meningiomas: A Tissue Microarray Digital Image Analysis.

Dimitrios Roukas1, Anastasios Kouzoupis2, Despoina Spyropoulou3

  • 1Department of Psychiatry, 417 Army Equity Fund Hospital (NIMTS), Athens, GRC.

Cureus
|July 27, 2022
PubMed
Summary
This summary is machine-generated.

Caspase 8 protein is overexpressed in 42% of meningiomas, correlating with higher tumor grade and mitotic activity. Targeting caspase 8 may offer new therapeutic strategies for specific meningioma patient groups.

Keywords:
apoptosiscaspaseimmunohistochemistrymeningiomatissue microarrays

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Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cellular Homeostasis

Background:

  • Caspases (cysteine-aspartic proteases) are key regulators of inflammation and apoptosis.
  • Meningiomas are the most prevalent primary central nervous system tumors in adults globally.

Purpose of the Study:

  • To investigate the association between caspase 8 expression and pathological characteristics of meningiomas.

Main Methods:

  • Immunohistochemistry assay on tissue microarray cores from 50 meningioma cases.
  • Digital image analysis for quantitative assessment of caspase 8 protein expression.

Main Results:

  • Caspase 8 overexpression identified in 42% (21/50) of meningiomas.
  • Significant correlation found between caspase 8 expression levels and tumor grade (p=0.001).
  • Caspase 8 expression also significantly correlated with mitotic index (p=0.002).

Conclusions:

  • Aberrant caspase 8 expression in meningiomas is linked to their differentiation grade and mitotic activity.
  • Therapeutic strategies aimed at enhancing caspase 8 and apoptosis show promise for specific meningioma subgroups.