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The Effect of Sepsis on Myocardial Function: A Review of Pathophysiology, Diagnostic Criteria, and Treatment

Nabeeha Khalid1, Pragnesh D Patel2, Rahmah Alghareeb3

  • 1Cardiology, Omar Hospital and Cardiac Centre, Lahore, PAK.

Cureus
|July 27, 2022
PubMed

Insights

Sepsis can cause heart problems, known as septic cardiomyopathy. This review explores its causes, diagnosis, and current treatment options for physicians managing septic shock patients.

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Sepsis and septic shock are significant global health challenges.
  • Sepsis-induced myocardial dysfunction, or septic cardiomyopathy, requires further investigation.
  • Current management focuses on infection control and organ support.

Purpose of the Study:

  • To elucidate the mechanisms underlying septic cardiomyopathy.
  • To review diagnostic criteria for septic cardiomyopathy.
  • To highlight current management strategies for sepsis-induced myocardial dysfunction.

Main Methods:

  • Comprehensive literature review of existing studies.
  • Analysis of pathophysiological mechanisms.
  • Evaluation of diagnostic tools (radiological and laboratory tests).

Main Results:

  • Multiple potential mechanisms contribute to septic cardiomyopathy.
  • Diagnostic criteria involve various clinical, laboratory, and imaging assessments.
  • Management strategies are evolving to address myocardial dysfunction in sepsis.

Conclusions:

  • Septic cardiomyopathy is a critical complication of sepsis.
  • Understanding its pathophysiology is key to developing targeted therapies.
  • Multidisciplinary approaches are essential for optimal patient outcomes.

Keywords:
cardiomyopathyechocardiographyinfectionmyocardial dysfunctionsepsisseptic shock

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