Recurrent Miller Fisher Syndrome

Area of Science:

• Neurology
• Autoimmune Diseases
• Ophthalmology

Background:

• Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome.
• It is characterized by ophthalmoplegia, ataxia, and areflexia.
• Recurrent MFS is exceptionally uncommon.

Observation:

• A case of recurrent MFS following an upper respiratory tract infection (URTI) is presented.
• The initial episode included external/internal ophthalmoplegia, areflexia, and ataxia.
• A subsequent, milder attack presented solely with ophthalmoplegia.

Findings:

• Both MFS episodes resolved spontaneously within one month.
• The recurrent attack showed a different symptom profile than the initial presentation.
• This case underscores the variable clinical manifestations of MFS.

Implications:

• Miller Fisher syndrome can mimic other neurological disorders, complicating diagnosis.
• Increased awareness of MFS, including its recurrent nature, is crucial for timely diagnosis.
• Prompt recognition facilitates appropriate management, even in rare presentations.