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Updated: Sep 3, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Development of a Multiepitope Vaccine Against SARS-CoV-2: Immunoinformatics Study.

Fatemeh Ghafouri¹, Reza Ahangari Cohan², Hilda Samimi³

¹Department of Biotechnology Faculty of Life Sciences and Biotechnology Shahid Beheshti University Tehran Iran.

JMIR Bioinformatics and Biotechnology

|July 27, 2022

Summary

A new computational vaccine design targets SARS-CoV-2 spike and envelope proteins. This multiepitope vaccine shows promise for a safe and effective COVID-19 pandemic strategy.

Keywords:

COVID-19 COVID-19 vaccine SARS-CoV-2 bioinformatics computational model envelope protein immunoinformatics informatics pandemic spike protein vaccine design

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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Area of Science:

Vaccinology
Computational Biology
Immunology

Background:

The SARS-CoV-2 outbreak, originating in China in December 2019, necessitates rapid vaccine development due to high transmissibility.
The urgent need for effective vaccines against SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) is driven by the global pandemic.

Purpose of the Study:

To computationally design a novel vaccine targeting the SARS-CoV-2 spike (S) protein and envelope (E) protein.
To identify conserved epitopes on S and E proteins for vaccine development.

Main Methods:

Utilized previously identified experimental epitopes of the S protein.
Predicted B-cell and Major Histocompatibility Complex (MHC) class II-restricted T-cell epitopes from the E protein.
Performed in silico vaccine design and immune response simulations.

Main Results:

The designed vaccine candidate demonstrated high affinity to MHC class II molecules.
In silico simulations indicated effective immune responses.
Identified conserved epitopes on SARS-CoV-2 E protein.

Conclusions:

The multiepitope vaccine targeting S and E proteins presents a potential new strategy against COVID-19.
The in silico approach offers a safe and efficient method for vaccine design.
This vaccine candidate warrants further investigation for its efficacy in combating the COVID-19 pandemic.