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Computed tomography-guided lung biopsy for molecular tests: a meta-analysis.

Jian-Hua Zhang1, Feng-Fei Xia2, Xiao-Shan Yang2

  • 1Department of Interventional Radiology, Fengjie People's Hospital, Chongqing, China.

Kardiochirurgia I Torakochirurgia Polska = Polish Journal of Cardio-Thoracic Surgery
|July 27, 2022
PubMed
Summary

Computed tomography (CT)-guided lung biopsy is effective for molecular testing in lung cancer, yielding a 95% adequacy rate. Epidermal growth factor receptor (EGFR) mutations were most common.

Keywords:
computed tomographylung biopsymeta-analysismolecular tests

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Area of Science:

  • Oncology
  • Pulmonology
  • Radiology

Background:

  • Computed tomography (CT)-guided lung biopsy is a common procedure for obtaining tissue samples.
  • Molecular testing is crucial for guiding lung cancer treatment decisions.

Purpose of the Study:

  • To evaluate the clinical effectiveness of CT-guided lung biopsy for molecular testing in lung cancer patients.
  • To determine the adequacy rates and mutation frequencies of key genes (EGFR, ALK, KRAS).

Main Methods:

  • A meta-analysis was conducted on studies published until July 2021, sourced from PubMed, Embase, and Cochrane Library.
  • Included studies focused on CT-guided lung biopsy for molecular testing, analyzing adequacy rates and mutation positivity.
  • 12 retrospective studies involving 2559 patients were analyzed.

Main Results:

  • The pooled adequacy rate for molecular testing was 95%.
  • The positive rates for epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) translocations were 49% and 7%, respectively.
  • Significant heterogeneity was observed in adequacy and EGFR mutation rates; no influencing variables were identified.

Conclusions:

  • CT-guided lung biopsy is an effective method for obtaining sufficient lung cancer samples for molecular analysis.
  • EGFR gene mutations were the most frequently identified in the analyzed patient cohort.