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Related Experiment Video

Updated: Sep 3, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
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Wasp stings and plasma exchange.

Sol Carriazo1, Alberto Ortiz1

  • 1IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.

Clinical Kidney Journal
|July 27, 2022
PubMed
Summary

Invasive Asian wasps, like Vespa mandarinia, can cause acute kidney injury. A new Wasp Sting Severity Score (WSS) may help guide early plasma exchange treatment for severe cases.

Area of Science:

  • Nephrology
  • Toxicology
  • Invasive Species Biology

Background:

  • Globalization and climate change facilitate the spread of invasive Asian wasps (e.g., Vespa mandarinia, V. velutina) into new regions like America and Europe.
  • These invasive wasps are increasingly linked to severe human health issues, including fatal outcomes and acute kidney injury (AKI).
  • Existing medical literature on wasp stings and AKI is limited and predominantly from Asian studies, leaving non-Asian nephrologists unfamiliar with this emerging threat.

Discussion:

  • A novel, four-item Wasp Sting Severity Score (WSS) was developed based on data from 1131 patients.
  • The score aims to identify patients at high risk for severe outcomes, such as those requiring hospitalization due to stings from species like Vespa mandarinia, V. velutina, and V. basalis.
  • The study suggests that a WSS score of 3 or higher warrants early plasma exchange (within 24 hours) for improved survival in critically ill patients.
Keywords:
acute kidney injurycontinuous venovenous haemofiltrationmortalitystingwasp

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Key Insights:

  • Plasma exchange demonstrated a mortality benefit in severely envenomated patients.
  • Continuous venovenous hemofiltration and hemoperfusion were not associated with reduced mortality.
  • The proposed Wasp Sting Severity Score (WSS) requires external validation but offers a potential tool for clinical decision-making.

Outlook:

  • The Wasp Sting Severity Score (WSS) needs validation in diverse populations to confirm its clinical utility.
  • Increased awareness among healthcare professionals globally is crucial, particularly in regions newly exposed to these invasive wasp species.
  • Further research should focus on the specific venom components responsible for nephrotoxicity and explore novel therapeutic strategies.