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[Systemic urticaria associated with autoimmune thyroiditis].

F Granier, C Marchand, A Navarranne

    La Revue De Medecine Interne
    |March 1, 1987
    PubMed
    Summary
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    Chronic urticaria may be linked to autoimmune thyroid disease. Treating Hashimoto's disease with levothyroxine resolved the patient's chronic urticaria, suggesting an autoimmune connection.

    Area of Science:

    • Immunology
    • Endocrinology
    • Dermatology

    Background:

    • Chronic urticaria is often idiopathic.
    • Autoimmune thyroid disease, such as Hashimoto's disease, is common, particularly in women.
    • Urticaria vasculitis is a distinct condition from chronic urticaria.

    Observation:

    • A patient presented with chronic urticaria and polyarthralgia.
    • The patient was diagnosed with Hashimoto's disease, indicated by nodular goiter, thyroid dysfunction, and high thyroid microsomal antibodies.
    • Skin biopsy revealed leucocytoclastic vasculitis.

    Findings:

    • Immunological studies showed minor abnormalities but no circulating immune complexes or complement abnormalities.
    • This case represents the first reported instance of urticaria vasculitis associated with thyroid autoimmunity.

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  • The patient's urticaria resolved completely after treatment with levothyroxine.

    • Implications:

    • The findings suggest a potential autoimmune etiology for chronic urticaria.
    • Systematic screening for anti-microsome antibodies is recommended for women with idiopathic chronic urticaria.
    • This case highlights the importance of considering systemic autoimmune conditions in dermatological presentations.