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Functions of the bone morphogenetic protein signaling pathway through non-coding RNAs
Ural Mukhametov1, Sergey Lyulin2, Dmitry Borzunov3
1Republican Clinical Hospital. G.G. Kuvatova, Ufa, 450071, Russian Federation.
Non-Coding RNA Research
|July 27, 2022
Summary
Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate bone morphogenetic proteins (BMPs) signaling. Dysregulation of these ncRNAs impacts cellular processes and disease development.
Area of Science:
- Molecular Biology
- Developmental Biology
- Genetics
Background:
- Bone morphogenetic proteins (BMPs) are crucial for skeletal and cartilage development and regeneration.
- BMP signaling is vital for blood vessel formation and mesenchymal stem cell (MSC) differentiation.
- Aberrant BMP signaling is linked to various disease states.
Purpose of the Study:
- To review the regulatory roles of non-coding RNAs (ncRNAs) in the BMP signaling pathway.
- To explore the involvement of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in BMP pathway modulation.
- To highlight the implications of ncRNA-mediated BMP regulation in cellular processes and disease.
Main Methods:
- Literature review of studies investigating ncRNAs and BMP signaling.
- Analysis of functional relationships between different classes of ncRNAs.
- Synthesis of current knowledge on ncRNA targets within the BMP pathway.
Main Results:
- ncRNAs, including miRNAs, lncRNAs, and circRNAs, are key epigenetic regulators of gene expression.
- These ncRNAs directly and indirectly influence the BMP signaling pathway.
- Dysfunctional ncRNA regulation of BMPs is associated with pathophysiological conditions, including oncogenesis.
Conclusions:
- ncRNAs play a significant role in controlling BMP signaling pathways.
- Understanding ncRNA-BMP interactions is essential for comprehending normal development and disease pathogenesis.
- Targeting ncRNAs offers potential therapeutic strategies for BMP-related disorders.
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