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Quantification of Liver Fat Content with the iATT Algorithm: Correlation with Controlled Attenuation Parameter.

Giovanna Ferraioli¹, Ambra Raimondi^1,2, Laura Maiocchi²

¹Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Università di Pavia, Viale Brambilla 74, 27100 Pavia, Italy.

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|July 27, 2022

Summary

The improved ultrasound attenuation coefficient (iATT) strongly correlates with the controlled attenuation parameter (CAP) for liver fibrosis assessment. This correlation remains robust even without strict adherence to liver stiffness measurement protocols.

Keywords:

NAFLD attenuation coefficient chronic liver disease concordance studies controlled attenuation parameter fat quantification fatty liver liver steatosis ultrasound

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Area of Science:

Medical Imaging
Hepatology
Ultrasound Technology

Background:

Non-invasive assessment of liver fibrosis is crucial.
Controlled Attenuation Parameter (CAP) is an established ultrasound-based metric.
An improved attenuation coefficient (iATT) on the Arietta 850 system warrants evaluation.

Purpose of the Study:

To assess the correlation between iATT and CAP.
To determine if protocol deviations impact iATT measurements.

Main Methods:

Consecutive individuals were enrolled for ultrasound assessment.
Pearson's r and Lin's concordance correlation coefficient (CCC) were used.
iATT and CAP values were compared with and without strict liver stiffness measurement protocols.

Main Results:

Strong correlations were observed between iATT and CAP (r=0.73 without protocol, r=0.71 with protocol).
Correlation was higher when interquartile range/median (IQR/M) was ≤ 15% (r=0.75).
Moderate to good concordance was found between iATT and CAP.

Conclusions:

iATT demonstrates a strong correlation with CAP for liver fibrosis staging.
iATT measurements are reliable even when strict protocols are not followed.
Optimal iATT-CAP correlation is achieved with IQR/M ≤ 15%.