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5G Electromagnetic Radiation Attenuates Skin Melanogenesis In Vitro by Suppressing ROS Generation.

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Antioxidants (Basel, Switzerland)
|July 27, 2022
PubMed
Summary

5G (28 GHz) electromagnetic radiation (EMR) was found to reduce skin pigmentation in melanoma cells and human skin models. This 5G EMR effect is linked to decreased melanin synthesis and reduced reactive oxygen species (ROS) production.

Keywords:
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Area of Science:

  • Biophysics
  • Dermatology
  • Cell Biology

Background:

  • Public interest in 5G electromagnetic radiation (EMR) health impacts is growing with 5G wireless technology.
  • Melanin synthesis is a complex process regulated by various factors, including reactive oxygen species (ROS).

Purpose of the Study:

  • To investigate the effects of 5G (28 GHz) EMR on skin pigmentation.
  • To determine the underlying mechanisms of 5G EMR's impact on melanogenesis.

Main Methods:

  • Exposure of murine melanoma cells (B16F10) and a 3D human epidermis model (Melanoderm™) to 5G (28 GHz) EMR.
  • Assessment of melanin synthesis, melanogenic enzyme expression (tyrosinase, TRP-1, TRP-2), and ROS production.
  • Utilized Fontana-Masson staining to visualize melanin distribution.

Main Results:

  • 5G (28 GHz) EMR attenuated α-MSH-induced melanin synthesis in B16F10 cells.
  • 5G EMR diminished dendritic cell formation and suppressed the upregulation of key melanogenic enzymes.
  • Irradiation of MelanoDerm™ models confirmed the anti-melanogenic effect of 5G EMR.
  • 5G EMR exposure reduced ROS production stimulated by α-MSH and H₂O₂.

Conclusions:

  • 5G (28 GHz) EMR can attenuate skin pigmentation.
  • The anti-melanogenic effect of 5G EMR is associated with the attenuation of ROS generation.
  • These findings provide insights into the biological effects of 5G EMR on skin cells.