FcγR-Mediated Trogocytosis 2.0: Revisiting History Gives Rise to a Unifying Hypothesis
Margaret A Lindorfer1, Ronald P Taylor1
1School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Antibodies (Basel, Switzerland)
|July 27, 2022
Summary
Trogocytosis, where cells internalize parts of other cells, is key in cancer immunotherapy. Understanding Fc receptor-mediated trogocytosis may lead to new cancer treatments.
Area of Science:
- Immunology
- Cancer Biology
- Cellular Biology
Background:
- Trogocytosis is a cellular process where receptors on one cell remove and internalize ligands from another.
- This phenomenon is increasingly recognized for its clinical implications in cancer immunotherapy.
Purpose of the Study:
- To explore the immunological mechanisms and clinical relevance of trogocytosis.
- To detail the role of Fc gamma receptor (FcγR)-mediated trogocytosis in cancer immunotherapy, specifically involving malignant B cells.
Main Methods:
- Review of existing literature on trogocytosis and FcγR interactions.
- Discussion of experimental evidence supporting FcγR-mediated trogocytosis.
- Hypothesis regarding the role of liver sinusoidal endothelial cells and FcγRIIb2.
Main Results:
- FcγR-expressing cells can remove and internalize CD20 and bound monoclonal antibodies (mAbs) from malignant B cells.
- Trogocytosis is implicated in immune adherence and antibody-induced immunosuppression.
- Evidence suggests a significant role for liver sinusoidal endothelial cells and the FcγRIIb2 receptor.
Conclusions:
- FcγR-mediated trogocytosis is a critical process in cancer immunotherapy.
- Further research into FcγR-mediated trogocytosis, particularly involving liver sinusoidal endothelial cells, is warranted.
- Elucidating these mechanisms could enable the development of novel therapeutic strategies to modulate trogocytosis for improved cancer treatment outcomes.
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