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Updated: Sep 3, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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The Role of PIM Kinases in Pediatric Solid Tumors

Janet Rae Julson1, Raoud Marayati1, Elizabeth Ann Beierle1

  • 1Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Cancers
|July 27, 2022
PubMed

Insights

PIM kinases are crucial in various cancers. This review details their function in pediatric cancers and summarizes current drug therapies and clinical trials targeting these enzymes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • PIM kinases are serine/threonine kinases implicated in cell survival, proliferation, and drug resistance.
  • Dysregulation of PIM kinase signaling is observed in various human malignancies.
  • Their specific role in pediatric cancers warrants detailed investigation.

Purpose of the Study:

  • To provide a comprehensive review of PIM kinases.
  • To elucidate the role of PIM kinases in pediatric carcinogenesis.
  • To summarize current therapeutic strategies targeting PIM kinases.

Main Methods:

  • Literature review and synthesis of existing research on PIM kinases.
  • Analysis of PIM kinase structure, expression, activity, and regulation.
  • Summary of preclinical and clinical data on PIM kinase inhibitors.

Main Results:

  • PIM kinases (PIM1, PIM2, PIM3) play significant roles in cell cycle progression and apoptosis evasion.
  • Aberrant PIM kinase activity is linked to the development and progression of several pediatric cancers.
  • Several pharmaceutical agents targeting PIM kinases are under investigation, with some in clinical trials.

Conclusions:

  • PIM kinases represent promising therapeutic targets for pediatric malignancies.
  • Targeting PIM kinases may offer novel treatment strategies for children with cancer.
  • Further research is needed to optimize PIM kinase-targeted therapies.
Keywords:
PIM kinasehepatoblastomaneuroblastomaosteosarcomapediatric

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