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Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
Salman Ahmed1, Waqas Alam2, Philippe Jeandet3
1Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan.
Abstract:
Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.
Insights
Marine peptides show promise as effective and safe treatments for prostate cancer (PCa), offering a natural alternative to conventional therapies with fewer side effects. This review highlights their potential to combat PCa through various mechanisms.
Area of Science:
- Marine biology
- Oncology
- Pharmacology
Background:
- Prostate cancer (PCa) is a leading cause of cancer death in men.
- Current PCa treatments often cause severe adverse effects, necessitating novel therapeutic strategies.
- Natural compounds, particularly from aquatic organisms, are being investigated for their anti-PCa potential.
Purpose of the Study:
- To review the therapeutic potential of marine peptides against prostate cancer (PCa).
- To highlight the efficacy and safety of marine peptides as alternative PCa treatments.
Main Methods:
- Literature review of studies on marine peptides and their effects on prostate cancer.
- Analysis of mechanisms of action, including effects on cell viability, apoptosis, migration, angiogenesis, and microtubule dynamics.
Main Results:
- Marine peptides exhibit anticancer properties against PCa cells.
- These peptides act through multiple mechanisms, including inducing apoptosis and inhibiting angiogenesis.
- Marine peptides demonstrate a favorable safety profile compared to conventional treatments.
Conclusions:
- Marine peptides represent a promising and safe therapeutic avenue for prostate cancer (PCa) treatment.
- Further research into marine peptides could lead to new, effective strategies for managing PCa.
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