Adipokines in Sleep Disturbance and Metabolic Dysfunction: Insights from Network Analysis.
Zhikui Wei1, You Chen2, Raghu P Upender1
1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Clocks & Sleep
|July 27, 2022
Summary
Obesity and sleep apnea disrupt metabolic health by altering adipokine networks. Leptin and adiponectin are key players, offering potential therapeutic targets for metabolic and sleep disorders.
Area of Science:
- Metabolic research
- Sleep science
- Network biology
Background:
- Adipokines are crucial secreted proteins influencing obesity, sleep, and metabolic health.
- The intricate relationship between adipokines, sleep, and metabolism necessitates integrated study approaches.
Purpose of the Study:
- To construct and analyze a molecular network of adipokines and their partners.
- To elucidate the role of adipokines in sleep-associated metabolic dysregulation.
Main Methods:
- Network creation and analysis of six key adipokines and associated molecular players.
- Utilizing network metrics to identify central nodes and influential factors.
Main Results:
- Obesity and obstructive sleep apnea identified as primary drivers of sleep-related metabolic dysfunction.
- Leptin and adiponectin emerged as central adipokines within the network.
- Leptin, AMP-activated protein kinase (AMPK), and fatty acid oxidation demonstrated broad network influence.
Conclusions:
- Network analysis reveals key adipokines and pathways implicated in metabolic and sleep disorders.
- Leptin, AMPK, and fatty acid oxidation represent promising interventional targets.
- Network-based strategies offer potential for discovering novel pharmaceutical targets.
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