Related Experiment Video
Updated: Sep 3, 2025
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
9.7K
Epidrugs: Toward Understanding and Treating Diverse Diseases
1Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.
Epigenomes
|July 27, 2022
Summary
This research explores epigenomic modifications and the development of epidrugs. These compounds offer new avenues for understanding and treating diverse diseases by regulating epigenetic changes.
Area of Science:
- Molecular Biology
- Genetics
- Pharmacology
Background:
- Epigenomic modifications are chemical alterations at specific chromosomal locations, varying between cells and modifiable by external factors.
- Recent advancements include genome-wide epigenomic mapping and identifying key regulatory proteins.
- Small molecules capable of modulating these modifications are under active development.
Discussion:
- This Special Issue focuses on "Epidrugs: Toward Understanding and Treating Diverse Diseases."
- It delves into the biological mechanisms of epigenome regulation.
- The development of novel therapeutic compounds targeting epigenetic pathways is a key theme.
Key Insights:
- Epigenomic modifications offer unique molecular signatures.
- External modulation of epigenetics is achievable through small molecules.
- Progress in identifying epigenome-modifying proteins is accelerating.
Outlook:
- The development of epidrugs holds significant therapeutic potential.
- Understanding epigenomic regulation is crucial for treating various diseases.
- This field is rapidly advancing, promising new treatment strategies.
Related Concept Videos
01:24Principles of Drug Action
6.5K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
6.5K
01:28Drug Therapy
92
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
92
01:26Drug Administration and Therapy Phases: Overview
691
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
691
01:26Drug Discovery: Overview
8.6K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.6K
01:02Prescription, Nonprescription and Orphan Drugs
838
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
838
01:27Combined Effects of Drugs: Synergism
4.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.6K