Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

7.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.0K
MicroRNAs01:22

MicroRNAs

3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.9K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author's response to comment on "Variations in clinical features and disease burden of myasthenia gravis between racial and ethnic groups: A retrospective cohort study of two national databases".

Journal of the neurological sciences·2026
Same author

Pathogenic properties of myasthenia gravis AChR autoantibodies associate with clinical response to efgartigimod.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Medication Usage in Motor Neuron Disease and Spinal Muscular Atrophy: Insights from the Muscular Dystrophy Association Neuromuscular Observational Research Data Hub.

Journal of clinical neuromuscular disease·2026
Same author

Integrative methylation and miRNA dysregulation in dlPFC reveal distinct molecular signatures of suicide and non-suicide subtypes in major depressive disorder.

Psychiatry and clinical neurosciences·2026
Same author

MicroRNA-425-3p: A Promising Biomarker and Candidate for Pharmacological Intervention in Neuropsychiatric Disabilities with Relevance to Major Depressive Disorder.

Neuropsychiatric disease and treatment·2026
Same author

Super Enhancer RNAs Rewrite the Molecular Script of Complex Gene Regulation in the MDD Brain.

Communications biology·2026
Same journal

An Optimized RT-qPCR Protocol for Comprehensive Analysis of microRNAs and mRNAs in <i>Mus musculus</i> Brain Tissues.

Non-coding RNA·2026
Same journal

Investigation of Long Non-Coding RNAs <i>H19</i> rs3741219, <i>MEG3</i> rs7158663, <i>POLR2E</i> rs3787016, and <i>ANRIL</i> rs10757274 with Breast Cancer Susceptibility and Clinicopathological Characteristics in a Mexican Population.

Non-coding RNA·2026
Same journal

Comprehensive lincRNA Transcriptome in Acute Myeloid Leukemia: Integrating Known and Newly Identified lincRNAs Across Pediatric and Adult Cohorts.

Non-coding RNA·2026
Same journal

Exploratory Machine Learning Analysis of circRNA-Derived Molecular Features in Autism Spectrum Disorder.

Non-coding RNA·2026
Same journal

Urinary Exosomal microRNAs as a Novel Approach to Study People with Multiple Sclerosis and Severe Gait Disability: A Preliminary Observation.

Non-coding RNA·2026
Same journal

Hnf1aos1 as a Metabolic Coordinator of Hepatic Lipid Homeostasis and Feedback Control.

Non-coding RNA·2026
See all related articles

Related Experiment Video

Updated: Sep 3, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.5K

miR-218: A Stress-Responsive Epigenetic Modifier.

Grant Schell1, Bhaskar Roy1, Kevin Prall1

  • 1Department of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Non-Coding RNA
|July 27, 2022
PubMed
Summary
This summary is machine-generated.

MicroRNA-218 (miR-218) plays a key role in brain stress response and may increase susceptibility to stress-related disorders like major depressive disorder (MDD). Its developmental expression impacts neuronal plasticity and adult stress adaptation.

Keywords:
animal modelsdepressionhuman brainmiR-218microRNAneuropsychiatrystress

More Related Videos

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

10.9K
Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.1K

Related Experiment Videos

Last Updated: Sep 3, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.5K
A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

10.9K
Measurements of Physiological Stress Responses in C. Elegans
10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

14.1K

Area of Science:

  • Neuropsychiatry
  • Epigenetics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) are crucial epigenetic regulators implicated in the pathophysiology of stress-associated mental disorders, notably major depressive disorder (MDD).
  • Aberrant miRNA expression impacts molecular pathways essential for brain stress adaptation and can lead to maladaptive changes in the stress axis.
  • miR-218, expressed in the hippocampus and prefrontal cortex, is a candidate miRNA influencing stress susceptibility.

Purpose of the Study:

  • To review the role of miR-218 in stress-induced neuropsychiatric conditions.
  • To emphasize the function of miR-218 in stress-related disorders and its developmental implications.

Main Methods:

  • Review of existing literature on miR-218, stress response, and neuropsychiatric disorders.
  • Analysis of studies using animal and cell-culture models to investigate miR-218's impact on the hypothalamic-pituitary-adrenal (HPA) axis.
  • Examination of miR-218's role in regulating key signaling pathways like glucocorticoid, serotonergic, and glutamatergic signaling.

Main Results:

  • miR-218 expression changes are linked to altered glucocorticoid, serotonergic, and glutamatergic signaling.
  • The Netrin-1/DCC signaling pathway is targeted by miR-218, influencing neuronal development and plasticity.
  • Increasing miR-218 expression from adolescence to adulthood suggests a developmental role in stress susceptibility.

Conclusions:

  • Altered miR-218 expression during development may negatively impact neuronal processes, increasing adult stress susceptibility.
  • miR-218 is a significant factor in the pathophysiology of stress-related neuropsychiatric disorders.
  • Further research, particularly in human subjects, is needed to fully elucidate miR-218's role in stress-related brain abnormalities.