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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

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Published on: July 27, 2022

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics.

Saeid Kargozar¹, Sahar Mollazadeh², Farzad Kermani²

¹Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.

Journal of Functional Biomaterials

|July 27, 2022

Summary

Hydroxyapatite nanoparticles (HAp NPs) show promise in cancer therapy by enabling targeted drug delivery and inhibiting cancer cell growth. Further research into HAp NPs for cancer theranostics could lead to advanced treatments.

Keywords:

bioceramics cancer treatment hydroxyapatite nanomaterials

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Area of Science:

Biomaterials Science
Nanotechnology
Oncology

Background:

Hydroxyapatite nanoparticles (HAp NPs) are explored for advanced cancer therapy beyond bone tissue engineering.
Their unique chemical structure facilitates sustained and targeted delivery of anticancer drugs, potentially reducing side effects.
HAp NPs can be modified for enhanced cancer cell targeting and inhibition of metastasis.

Purpose of the Study:

To review the applications of HAp NPs in cancer theranostics.
To highlight the potential of HAp NPs in drug delivery, cancer cell inhibition, and imaging.
To discuss current limitations and future research directions for HAp NP-based cancer treatments.

Main Methods:

Review of current literature on HAp NP applications in cancer therapy and diagnosis.
Analysis of HAp NP properties for drug loading, targeted delivery, and theranostic capabilities.
Examination of HAp NP use in scaffolds for tissue regeneration post-cancer treatment.

Main Results:

HAp NPs offer a versatile platform for sustained drug release and targeted cancer therapy.
Surface modifications enable smart targeting and killing of cancer cells with minimal impact on healthy cells.
Superparamagnetic HAp NPs show potential for in vivo imaging and early cancer detection.
HAp NPs are being investigated for fabricating scaffolds for cancerous tissue treatment and regeneration.

Conclusions:

HAp NPs represent a promising theranostic agent for improved cancer treatment strategies.
Further research is needed to overcome current limitations and fully realize the potential of HAp NPs in oncology.
HAp NP-based approaches offer new avenues for developing effective and less toxic cancer therapies.