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Analytical Methods for Nanomaterial Determination in Biological Matrices.

Magdalini Vladitsi1, Charalampia Nikolaou1, Natasa P Kalogiouri1

  • 1Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.

Methods and Protocols
|July 27, 2022
PubMed
Summary

This review covers analytical methods for characterizing and quantifying nanomaterials in biological samples. Developing these methods is crucial for assessing risks associated with the increasing use of nanoparticles.

Keywords:
AAS (Atomic Absorption Spectrometry)ICP-MS (inductively coupled plasma-mass spectrometry)analytical chemistryinstrumental analysisnanoparticlesnanotechnology

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Environmental Science

Background:

  • Nanomaterials, defined by the International Organization for Standardization (ISO) as materials with at least one dimension between 1 and 100 nm, are increasingly prevalent in industry and consumer products.
  • The widespread application of nanomaterials necessitates a thorough assessment of their potential environmental and biological risks.
  • Reliable analytical methodologies are essential for accurately characterizing and quantifying nanomaterials in diverse matrices to manage these risks.

Purpose of the Study:

  • To review recent advancements in analytical methodologies for nanomaterial characterization.
  • To summarize techniques for the determination and quantification of nanoparticles within biological matrices.
  • To highlight the importance of analytical method development for risk assessment.

Main Methods:

  • Review of current scientific literature on analytical techniques for nanomaterials.
  • Focus on methods applicable to biological samples.
  • Synthesis of trends in nanoparticle characterization and quantification.

Main Results:

  • Identification of key analytical trends for nanomaterial characterization.
  • Summary of methodologies for nanoparticle determination in biological environments.
  • Emphasis on the need for robust analytical tools.

Conclusions:

  • Accurate characterization and quantification of nanomaterials in biological matrices are critical.
  • Advancements in analytical methods are vital for understanding and mitigating risks.
  • This review provides an overview of current trends to guide future research and regulatory efforts.