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Vaccinations01:51

Vaccinations

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Overview
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Vaccination and Antibody Testing in Cats.

Herman Egberink1, Tadeusz Frymus2, Katrin Hartmann3

  • 1Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, University of Utrecht, 3584 CL Utrecht, The Netherlands.

Viruses
|July 27, 2022
PubMed
Summary

Antibody testing in cats can verify vaccine effectiveness and guide re-vaccination schedules. While useful for feline panleukopenia, its application for other feline herpesvirus and calicivirus vaccines requires further research.

Keywords:
DOIduration of immunityfelineimmunizationmaternal antibodiestitre testingvaccine

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Area of Science:

  • Veterinary immunology
  • Feline infectious diseases
  • Vaccinology

Background:

  • Vaccines are crucial for feline health, stimulating immune responses against serious diseases.
  • Current vaccination guidelines rely on minimal duration of immunity (DOI), with varying antibody titre correlations for different feline pathogens.
  • Feline panleukopenia (FPV) antibody titres correlate with protection, unlike feline calicivirus (FCV) and feline herpesvirus (FHV).

Purpose of the Study:

  • To review current knowledge and expert opinions on the application of antibody testing in cats.
  • To explore the utility of antibody testing for assessing vaccine response and informing vaccination protocols.

Main Methods:

  • Review of existing literature and expert consensus from the European Advisory Board on Cat Diseases (ABCD).
  • Discussion of antibody testing methods, including laboratory diagnostics and point-of-care (POC) tests.
  • Analysis of antibody testing applications in adult cats, kittens, and shelter environments.

Main Results:

  • Antibody testing can confirm successful vaccination and inform re-vaccination intervals in adult cats.
  • In shelters, antibody testing aids in controlling FPV outbreaks by identifying susceptible cats.
  • Testing for kittens is proposed but currently limited by cost and impracticality of monitoring maternal antibodies.

Conclusions:

  • Antibody testing offers valuable insights into feline immune status post-vaccination.
  • Its role in guiding vaccination strategies for individual cats is promising but requires further validation and cost-effectiveness analysis.
  • Further research is needed to clarify the correlation between antibody titres and protection for FCV and FHV infections.