Related Experiment Video

Updated: Sep 3, 2025

Murine Ileocolic Bowel Resection with Primary Anastomosis

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Probiotics/Synbiotics to Reduce Infectious Complications after Colorectal Surgery: A Systematic Review and

Julie Veziant^1,2,3, Mathilde Bonnet³, Bob V Occean⁴

¹Department of Digestive and Oncological Surgery, University Hospital Lille, 59000 Lille, France.

|July 27, 2022

Summary

Probiotics and synbiotics significantly reduce infectious complications, including pulmonary and urinary infections, after colorectal surgery. Further research is needed to optimize their use in enhanced recovery programs.

Area of Science:

Gastroenterology and Surgical Research
Microbiome and Probiotic Therapeutics

Background:

Infectious complications pose a significant risk following colorectal surgery (CRS).
Enhanced recovery after surgery (ERAS) programs aim to optimize patient outcomes, but infectious complications remain a challenge.
Perioperative interventions are explored to mitigate these risks.

Purpose of the Study:

To evaluate the efficacy of probiotics/synbiotics in reducing infectious complications after CRS.
To determine if probiotics or synbiotics should be integrated into perioperative care and ERAS protocols.
To identify optimal formulations, types, and timing for probiotic/synbiotic administration in CRS.

Main Methods:

A systematic review and quantitative meta-analysis adhering to PRISMA 2020 guidelines.
Inclusion of randomized controlled trials comparing perioperative probiotics/synbiotics with placebo or standard care in elective CRS.
Primary outcomes: overall infectious complications and surgical site infections (SSIs). Secondary outcomes: pulmonary, urinary, wound infections, and anastomotic leaks.

Main Results:

Twenty-one trials (15 probiotics, 6 synbiotics) were analyzed.
Probiotics/synbiotics significantly reduced overall infectious complications (RR 0.59) and SSIs (RR 0.70).
Significant reductions were observed in pulmonary (RR 0.35) and urinary infections (RR 0.41), but not anastomotic leaks or wound infections.

Conclusions:

Probiotics and synbiotics are effective in reducing infectious complications post-colorectal surgery.
The most pronounced effects were seen in preventing pulmonary and urinary infections.
Further investigation into optimal formulations and duration is required before definitive integration into ERAS programs.

Keywords:

colorectal meta-analysis postoperative complications probiotics surgery synbiotics

More Related Videos

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...

Inflammatory Bowel Disease IV: Pharmacological Management

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

Drugs for Treatment of Diarrhea-Predominant IBS

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

Articles linked to this work by shared authors, journal, and citation graph.

Work restrictions and Unfitness to work: Prevalence and risk factors a cross-sectional study on 70 000 occupational visits.

PloS one·2026

Totum-63, a plant-based polyphenol-rich extract, in prediabetes or early-stage type 2 diabetes: an international, multicenter, randomized controlled trial.

Nature communications·2026

Effect of weight loss interventions on liver-related health in children and adolescents with obesity: a systematic review and meta-analyses.

International journal of obesity (2005)·2026

Evaluation of the Impact of a Smartphone App on Adherence to an Exercise Program in People With Chronic Low Back Pain: Randomized Controlled Trial.

JMIR mHealth and uHealth·2026

Discomfort of noninvasive ventilation, high flow nasal cannula oxygen, and conventional oxygen implemented after extubation in non-COPD patients.

Critical care (London, England)·2026

Financial hardship and pain among cancer survivors: a French nationwide cross-sectional analysis.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

See all related articles