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[Effect of somatostatin on postoperative gastrointestinal function and stress level in children with acute abdomen: a
Bo-Xiang Qi1, Lei Zhu1, Li-Ping Sheng1
1Surgical Intensive Care Unit, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221006, China.
Insights
Somatostatin administration in children with acute abdomen significantly reduces postoperative stress and improves gastrointestinal function. This treatment also lowers complication rates, leading to better patient outcomes and faster recovery.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Endocrinology
Background:
- Acute abdomen in children presents significant postoperative challenges, including delayed gastrointestinal recovery and elevated stress responses.
- Effective management strategies are crucial to mitigate these complications and improve surgical outcomes.
Purpose of the Study:
- To evaluate the efficacy of somatostatin in managing postoperative gastrointestinal function and stress levels in pediatric patients with acute abdomen.
- To compare the incidence of complications and recovery times between children receiving somatostatin and those receiving conventional treatment.
Main Methods:
- A randomized controlled trial involving 102 children with acute abdomen, divided into a somatostatin (observation) group and a conventional treatment (control) group.
- Serum levels of stress hormones (endothelin-1, adrenocorticotropic hormone, cortisol) and gastrointestinal hormones (gastrin, motilin) were measured preoperatively and postoperatively.
- Postoperative recovery parameters, including time to flatus, bowel sounds, defecation, and length of hospital stay, were assessed.
Main Results:
- The somatostatin group exhibited significantly lower levels of endothelin-1, adrenocorticotropic hormone, and cortisol postoperatively compared to the control group.
- Significantly higher levels of motilin and gastrin were observed in the somatostatin group on postoperative day 5.
- Patients receiving somatostatin experienced shorter times to first flatus, bowel sounds, and defecation, a reduced hospital stay, and a lower complication rate (6% vs. 24%).
Conclusions:
- Somatostatin effectively attenuates the postoperative stress response in children undergoing surgery for acute abdomen.
- The administration of somatostatin improves gastrointestinal motility and function, leading to accelerated recovery.
- Somatostatin treatment is associated with a reduced incidence of postoperative complications, contributing to a favorable prognosis in pediatric acute abdomen cases.
Objectives:
To study the effect of somatostatin on postoperative gastrointestinal function and stress level in children with acute abdomen.
Methods:
A total of 102 children with acute abdomen who underwent surgery in Xuzhou Children's Hospital from August 2019 to June 2021 were enrolled as subjects and were randomly divided into an observation group and a control group, with 51 children in each group. The children in the control group were given conventional treatment such as hemostasis and anti-infective therapy after surgery, and those in the observation group were given somatostatin in addition to conventional treatment. Peripheral blood samples were collected from both groups before surgery and on days 1 and 5 after surgery. The two groups were compared in terms of the serum levels of endothelin-1 (ET-1), adrenocorticotropic hormone (ACTH), cortisol, gastrin, and motilin, postoperative recovery, and the incidence rate of complications.
Results:
There was no significant difference in the serum levels of ET-1, ACTH, cortisol, gastrin, and motilin between the two groups before surgery (P>0.05). Compared with the control group, the observation group had significantly lower serum levels of ET-1, ACTH, and cortisol on days 1 and 5 after surgery (P<0.05) and significantly higher levels of motilin and gastrin on day 5 after surgery (P<0.05). Compared with the control group, the observation group had significantly shorter time to first passage of flatus, first bowel sounds, and first defecation after surgery, as well as a significantly shorter length of hospital stay (P<0.05). The incidence rate of complications in the observation group was significantly lower than that in the control group (6% vs 24%, P<0.05).
Conclusions:
In children with acute abdomen, somatostatin can significantly reduce postoperative stress response, improve gastrointestinal function, and reduce the incidence rate of complications, thereby helping to achieve a good prognosis.
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