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Updated: Sep 3, 2025
05:46
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
17.9K
Cabotegravir: The first long-acting injectable for HIV pre-exposure prophylaxis
Caitlin Prather1, Chaeok Jeon1
1Department of Pharmacy, Inova Health System, Fairfax, VA, USA.
Summary
Cabotegravir, a long-acting injectable, is a safe and effective option for HIV pre-exposure prophylaxis. Clinical trials show it is non-inferior to daily oral options, with injection site reactions being common.
Area of Science:
- Pharmacology and clinical science
- Infectious disease prevention
Background:
- Review of cabotegravir for HIV pre-exposure prophylaxis (PrEP).
- Exploration of its pharmacology, efficacy, and safety based on clinical trial data.
Approach:
- Narrative review of PubMed/MEDLINE articles (March 2014-December 2021).
- Inclusion of data from prescribing information and scientific meetings.
- Keywords: cabotegravir, Apretude, long-acting injectable, human immunodeficiency virus, pre-exposure prophylaxis.
Key Points:
- Cabotegravir is the first FDA-approved long-acting injectable for HIV PrEP.
- Phase 3 trials demonstrate non-inferiority to daily oral regimens.
- Injection-site reactions are common (up to 81%), and formulation costs are a consideration.
Conclusions:
- Cabotegravir offers a novel bimonthly injectable PrEP option for high-risk individuals.
- It is approved as safe and effective for HIV prevention.
- Consideration of cost and side effects like injection-site reactions is necessary.
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