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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Area of Science:

  • Neurology
  • Infectious Diseases
  • Parasitology

Background:

  • Angiostrongylus cantonensis is a significant cause of eosinophilic meningitis globally.
  • Human infections often manifest with neurological symptoms like headache and neck stiffness.

Observation:

  • A patient with PCR-confirmed Angiostrongylus cantonensis infection presented with small fiber neuropathy (SFN) without headache.
  • SFN diagnosis was supported by skin biopsy findings.

Findings:

  • Standard neuropathy treatments were ineffective for the patient.
  • Intravenous lidocaine provided significant symptom relief for the chronic neuropathy.

Implications:

  • Angiostrongylus cantonensis should be considered in the differential diagnosis of small fiber neuropathy.
  • The parasite's potential to cause long-term neurological damage requires clinical recognition.