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Published on: August 16, 2018
Nickel-Catalyzed Reductive Borylation of Enaminones via C(sp2)-N Bond Cleavage
Xiaoning Li1,2, Zunsheng Chen1, Yan Liu1
1School of Pharmacy, Gannan Medical University, Ganzhou 341000, PR China.
Abstract:
The cleavage and transformation of alkenyl C(sp2)-N bonds is a significant synthetic challenge. Herein we described an unprecedented nickel-catalyzed reductive borylation of enaminones to synthesize β-ketone boronic esters. Notably, B2pin2 played the dual role in this process, and water served as a hydrogen source, which was transferred to target products. The air-stable nickel catalyst was applied to the cleavage of alkenyl C(sp2)-N bonds, concomitant with the reductive process of the alkenyl boronic ester intermediates, on the basis of the mechanism study.
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