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Cissus quadrangularis extract mitigates diabetic cardiomyopathy by inhibiting RAAS activation, inflammation and

Anees Ahmed Syed1,2, Mohammad Irshad Reza1, Mohammad Shafiq2,3

  • 1Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, India.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|July 27, 2022
PubMed

Insights

Ethanolic extract of Cissus quadrangularis (EECQ) effectively treats diabetic cardiomyopathy by improving cardiac function and reducing inflammation and oxidative stress. This natural compound shows promise as a therapeutic agent for this age-related heart condition.

Area of Science:

  • Cardiology
  • Pharmacology
  • Diabetology

Background:

  • Diabetic cardiomyopathy (DCM) is an age-related condition characterized by hyperglycemia, cardiac dysfunction, and myocardial abnormalities.
  • Cissus quadrangularis is a traditional medicinal plant with various health benefits.
  • This study investigates the potential of Cissus quadrangularis extract in managing DCM.

Purpose of the Study:

  • To evaluate the therapeutic effects of ethanolic extract of Cissus quadrangularis (EECQ) on high-fat diet/streptozotocin-induced diabetic cardiomyopathy in rats.
  • To assess the impact of EECQ on cardiac biomarkers, inflammatory markers, and reactive oxygen species (ROS) production in DCM.

Main Methods:

  • Rats were induced with DCM using a high-fat diet and streptozotocin.
  • Treatment involved oral administration of EECQ (200 mg/kg/day) for six weeks.
  • Cardiac biomarkers, inflammatory markers, ROS, and glucose/lipid profiles were analyzed.

Main Results:

  • EECQ improved glucose tolerance, insulin sensitivity, and hypercholesterolemia.
  • Cardiac dysfunction markers (CKMB, LDH) and hypertrophic biomarkers (ANP, BNP) were reduced by EECQ.
  • EECQ treatment decreased oxidative stress, ROS production, and cardiac inflammation, also alleviating Angiotensin II and renin levels.

Conclusions:

  • Ethanolic extract of Cissus quadrangularis demonstrates significant therapeutic potential against diabetic cardiomyopathy.
  • EECQ may serve as a valuable natural therapeutic agent for managing DCM and its associated complications.
Abstract

Keywords:
Cissus quadrangularisRAAS systemcardiac dysfunctiondiabetic cardiomyopathyoxidative stress

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