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[Immunosuppressive therapy in clinical practice]
In clinical practice immunosuppressive therapy is performed by means of glucocorticoids in most patients. In addition, some patients are given alkylating agents (cytoxan, chlorambucil) or purine analogues (azathioprine). Recently a new immunosuppressive drug, cyclosporine A, has been developed. The mechanisms of action of these four compounds are discussed, for which purpose a simple model of the immunological network is presented. The present indications for the use of cyclosporine A in clinical practice are discussed.
In clinical practice immunosuppressive therapy is performed by means of glucocorticoids in most patients. In addition, some patients are given alkylating agents (cytoxan, chlorambucil) or purine analogues (azathioprine). Recently a new immunosuppressive drug, cyclosporine A, has been developed. The mechanisms of action of these four compounds are discussed, for which purpose a simple model of the immunological network is presented. The present indications for the use of cyclosporine A in clinical practice are discussed.