Related Experiment Video

Updated: Sep 3, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

278

Acute and chronic kidney complications in children with type 1 diabetes mellitus

Giulio Rivetti1, Brenden E Hursh2, Emanuele Miraglia Del Giudice1

  • 1Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Naples, Italy.

Pediatric Nephrology (Berlin, Germany)
|July 27, 2022
PubMed

Insights

Children with type 1 diabetes mellitus (T1DM) face significant kidney risks, with acute kidney injury (AKI) at onset potentially leading to chronic kidney disease (CKD). Poor glycemic control further exacerbates long-term kidney damage in T1DM patients.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Diabetology

Background:

  • Type 1 diabetes mellitus (T1DM) significantly elevates children's risk for kidney complications.
  • Acute kidney injury (AKI) affects up to 65% of children at T1DM onset, serving as a precursor to chronic kidney disease (CKD).

Approach:

  • This review synthesizes current knowledge on the renal effects of T1DM.
  • It examines both the immediate and long-term impacts of diabetes on kidney health in pediatric populations.

Key Points:

  • Early-onset AKI in T1DM is a critical risk factor for developing CKD.
  • Subsequent poor glycemic control in T1DM is linked to diabetic kidney disease progression.
  • Understanding these acute and chronic effects is vital for managing long-term kidney prognosis.

Conclusions:

  • T1DM poses a dual threat to kidney function, with risks manifesting both at disease onset and throughout its course.
  • Effective management of T1DM, particularly glycemic control, is crucial for mitigating kidney damage and preserving long-term renal health in children.

Keywords:
Acute kidney injuryChildrenChronic kidney diseaseDiabetic kidney diseaseType 1 diabetes mellitus

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