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Updated: Sep 3, 2025
Simultaneous ex vivo Functional Testing of Two Retinas by in vivo Electroretinogram System
Published on: May 6, 2015
Documentation of recovery from vitamin A deficiency-related retinopathy via multimodal imaging and electroretinogram
Stephanie Choi1, Saagar Pandit1, Sachi A Patil2
1Department of Ophthalmology, New York University, Floor 3, 222 E 41st Street, New York City, NY, 10017, USA.
Purpose:
To describe vitamin A deficiency using multimodal functional visual assessments and imaging.
Methods/Case:
A 50-year-old female with past medical history significant for Roux-en-Y gastric bypass surgery complained of nyctalopia and "yellowing" of vision.
Results:
Vitamin A levels were noted to be < 0.06 mg/L (normal 0.3-0.12 mg/L). Fundus examination was notable for peripheral yellow punctate lesions, superior arcuate defects on HVF 30-2 testing, an indistinct ellipsoid zone on SD-OCT, and absent rod responses and severely reduced amplitudes for the cone photoreceptors on full-field ERG. These findings resolved with initiation of parenteral vitamin A supplementation.
Conclusion:
This report documents an example of vitamin A deficiency in the developed world. We aim to provide a comprehensive description of clinical examination and multimodal imaging findings before and after vitamin supplementation for vitamin A deficiency.
