Advanced Vesicular Systems for Antifungal Drug Delivery

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Shaimaa Mosallam1, Rofida Albash2, Manar Adel Abdelbari3

  • 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza, 12585, Egypt. shaimaamosallam@o6u.edu.eg.

AAPS Pharmscitech
|July 27, 2022
PubMed

Insights

Advanced vesicular carriers enhance antifungal drug efficacy and safety for opportunistic fungal infections. These biocompatible systems improve drug stability, solubility, and bioavailability, overcoming limitations of conventional treatments.

Area of Science:

  • Mycology and Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biocompatible Materials

Background:

  • Fungal infections are a growing global health concern, particularly affecting immunocompromised individuals.
  • Opportunistic fungi like Candida, Fusarium, and Aspergillus species cause diverse infections, ranging from superficial to systemic.
  • Conventional antifungal drugs often exhibit poor physicochemical properties, high toxicity, and significant systemic side effects.

Purpose of the Study:

  • To review advanced vesicular carrier systems for encapsulating antifungal drugs.
  • To explore how these carriers improve drug efficacy and reduce adverse effects.
  • To address challenges in stability, solubility, bioavailability, and safety associated with antifungal therapies.

Main Methods:

  • Literature review of advanced vesicular drug delivery systems.
  • Analysis of biocompatible carriers for antifungal drug encapsulation.
  • Evaluation of carrier impact on drug physicochemical properties and therapeutic outcomes.

Main Results:

  • Vesicular carriers demonstrate potential for enhanced encapsulation of antifungal agents.
  • These systems can significantly improve drug solubility, stability, and bioavailability.
  • Biocompatible carriers show promise in reducing systemic toxicity and improving the safety profile of antifungals.

Conclusions:

  • Advanced vesicular carriers offer a promising strategy to overcome limitations of conventional antifungal treatments.
  • These drug delivery systems can enhance the therapeutic efficacy and safety of antifungal medications.
  • Further research into biocompatible vesicular carriers is warranted for improved management of fungal infections.
Keywords:
Advanced vesicular carriersAntifungal drugsConventional systemsFungal infections

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