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Petrositis caused by fluconazole-resistant candida: case report and literature review

Ling Jin1, Shuangxi Liu1, Shiwang Tan1

  • 1Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Putuo, Shanghai, 200065, China.

BMC Infectious Diseases
|July 27, 2022
PubMed
Abstract

Insights

Fungal petrositis, a rare complication of otitis media, can be effectively treated with antifungal drugs. Metagenomic next-generation sequencing (mNGS) aids in identifying fungal pathogens for targeted treatment.

Area of Science:

  • Infectious Diseases
  • Otolaryngology
  • Medical Mycology

Background:

  • Petrositis is a rare, fatal complication of otitis media, often caused by bacterial or fungal infections.
  • Fungal petrositis presents with symptoms including chronic ear pain, severe headache, facial palsy, and diplopia.

Observation:

  • This case report details a patient with fungal petrositis.
  • Diagnosis was confirmed via imaging, bacterial culture, pathology, and blood metagenomic next-generation sequencing (mNGS).

Findings:

  • Antifungal drug therapy proved to be a conservative yet effective treatment.
  • Metagenomic next-generation sequencing (mNGS) identified the fungal pathogen, guiding treatment adjustments.

Implications:

  • mNGS is valuable for diagnosing and managing fungal infections, especially when conventional methods fail or drug resistance is suspected.
  • This approach allows for precise, targeted antifungal drug selection, improving patient outcomes in complex cases of petrositis.
Keywords:
CandidaDiagnosesDrug treatmentGradenigo's syndromePetrositis

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