[Rachianesthesia with morphine: analgesic efficacy of the addition of clonidine or magnesium sulfate post caesarean section]

the aim of this study was to evaluate Target the effect of the addition of clonidine or magnesium sulfate of morphine, administered through IT on the duration of analgesia after spinal anesthesia for cesarean section.

75 women in labor, ASA I or II, proposed programmed or semi-urgent caesarean section, were included in this study. They were randomized into three groups: Group morphine or witness (GM), Magnesium Group (GMg), clonidine group (CG). The primary endpoint was the time between the completion of spinal anesthesia and the first analgesic request.

The time to first analgesic request was superior, 286.76 (52.25) mn in the GC and 237.40 (73.67) mnin GMg against 209.68 (36.09)mn GM (p <0.001) in connection with the literature data. The EVA average scores at rest and during exercise in the first 24 postoperative hours were lower in groups and GC GMg compared to GM. Overall satisfaction was good in parturients with no significant difference in the groups. The duration of motor block was 193.68 (33.37) min in the GC against 141.76 (29.80) min in GM and 135.92 (23.14) min in the GMg (p <0.001). We noted a significant incidence of somnolence. Hemodynamic parameters were similar between the three groups.

In parturients operated on by cesarean section under spinal anesthesia, the addition of 75 mg magnesium sulfate or 75µg clonidine 100 µg of morphine in IT prolongs significantly the duration of the first analgesic postoperatively demand and reduced scores pain 24 hours without increasing the incidence of adverse effects.