Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium...

Area of Science:

• Biomarker Detection
• Cardiovascular Disease Diagnostics
• Biosensor Technology

Background:

• Cardiovascular diseases are a leading cause of global mortality, necessitating rapid diagnostic tools.
• Myoglobin is a critical biomarker for acute myocardial infarction, indicating heart muscle damage.
• Timely detection of myoglobin is crucial for patient survival and effective treatment.

Purpose of the Study:

• To develop and characterize a novel photoelectrochemical immunosensor for sensitive myoglobin detection.
• To evaluate the performance of the developed immunosensor for diagnosing acute myocardial infarction.

Main Methods:

• Fabrication of a fluorine-doped tin oxide electrode modified with CdSeS/ZnSe quantum dots and barium titanate (BTO).
• Characterization using SEM, EDX, TEM, XRD, EIS, and amperometry.
• Detection of myoglobin via anodic photocurrent measurement at 0 V (vs. Ag/AgCl) and pH 7.4.

Main Results:

• The immunosensor exhibited a linear response to myoglobin concentrations ranging from 0.01 to 1000 ng mL⁻¹.
• High sensitivity and specificity were demonstrated for myoglobin detection.
• An average recovery rate of 95.7-110.7% was achieved, indicating reliable quantification.

Conclusions:

• The developed CdSeS/ZnSQDS/BTO photoelectrochemical immunosensor offers a promising platform for rapid and accurate myoglobin detection.
• This biosensor can significantly aid in the early diagnosis of acute myocardial infarction.
• The study highlights the potential of quantum dot-based immunosensors in cardiovascular disease diagnostics.