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Bilateral Orbital Plasmacytomas With Orbital Compartment Syndrome
Rachel E Pyon1, Grace C Wang1,2, Yan Chu1
1Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, USA.
Cureus
|July 28, 2022
Summary
Orbital plasmacytomas, rare soft-tissue plasma cell neoplasms linked to multiple myeloma, present unique challenges. This case highlights their aggressive nature and the need for prompt, multidisciplinary care.
Area of Science:
- Oncology
- Ophthalmology
- Hematology
Background:
- Orbital plasmacytomas are uncommon extramedullary plasma cell neoplasms.
- They are associated with monoclonal proteins and can manifest with ocular symptoms like proptosis and vision changes.
Observation:
- A 60-year-old female with multiple myeloma developed bilateral orbital plasmacytomas post-stem cell transplant.
- Initial treatment included chemotherapy and radiation therapy, leading to temporary improvement.
Findings:
- The patient experienced disease progression with parotid gland involvement three months later.
- Orbital plasmacytomas are associated with poorer remission and survival rates compared to other extramedullary sites.
Implications:
- Early diagnosis and multidisciplinary management are crucial for high-risk patients with orbital plasmacytomas.
- Aggressive treatment strategies are needed to improve outcomes and manage symptoms.
