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Dynamic Transcriptomic Profiling During Liver Development in Schizothorax Prenanti.

Jiahui Ni1, Peng Zhu1, Qilang Mo1

  • 1College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.

Frontiers in Physiology
|July 28, 2022
PubMed
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This study reveals key gene expression changes during fish liver development. It identifies altered lipid and glucose metabolism pathways, providing insights into teleost liver maturation.

Area of Science:

  • Comparative genomics
  • Fish biology
  • Molecular endocrinology

Background:

  • The liver is crucial for fish metabolism and detoxification.
  • The gene regulatory network governing postnatal liver development in teleosts is largely uncharacterized.

Purpose of the Study:

  • To investigate the gene expression patterns during postnatal liver development in *S. prenanti*.
  • To elucidate the molecular mechanisms underlying metabolic changes in the developing fish liver.

Main Methods:

  • Transcriptome analysis of *S. prenanti* liver across three developmental stages.
  • Oil red O and PAS staining to assess lipid and glycogen content.
  • Differential gene expression analysis and pathway enrichment analysis.
Keywords:
RNA-seqS. prenanti.developmentlivermetabolism

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Main Results:

  • 1692 differentially expressed genes (DGEs) were identified across developmental stages.
  • Liver lipid content increased, while glycogen content decreased with development.
  • Genes involved in fatty acid biosynthesis were upregulated, while lipid degradation genes were downregulated in later stages.
  • Glycolysis, gluconeogenesis, and glycogenolysis genes were upregulated in earlier stages.
  • The CYP450 pathway, cell cycle, and amino acid metabolism pathways were activated during liver maturation.

Conclusions:

  • This study provides a comprehensive gene expression profile for *S. prenanti* liver development.
  • The findings highlight significant shifts in lipid and glucose metabolism during liver maturation.
  • The identified gene regulatory network offers a foundation for future research on fish liver physiology and metabolism.