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[Blocking Adenosine/A2AR Pathway for Cancer Therapy]

Jia Liu1, Yuequan Shi1, Xiaoyan Liu1

  • 1Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|July 28, 2022
PubMed

Insights

Blocking the adenosine A2A receptor (A2AR) pathway shows promise for enhancing anti-tumor immunity. Clinical trials indicate A2AR antagonists are safe and effective in cancer patients, alone or combined with other treatments.

Area of Science:

  • Immunology
  • Oncology
  • Pharmacology

Background:

  • Adenosine, abundant in the tumor microenvironment, suppresses immune responses via the adenosine A2A receptor (A2AR).
  • A2AR is expressed on immune cells, inhibiting anti-tumor immunity.
  • Blocking the adenosine signaling pathway presents a therapeutic strategy to enhance anti-tumor immunity.

Purpose of the Study:

  • To review the adenosine signaling pathway and its role in tumor immunity.
  • To highlight the therapeutic potential of adenosine A2A receptor (A2AR) blockade in cancer therapy.

Main Methods:

  • Review of preclinical data on adenosine/A2AR inhibition.
  • Analysis of ongoing and completed clinical trials of A2AR antagonists.
  • Evaluation of safety and efficacy of A2AR antagonists as monotherapy and in combination.

Main Results:

  • Preclinical studies demonstrate prospective anti-tumor activity of adenosine/A2AR inhibition.
  • Clinical trials show A2AR antagonists are well-tolerated in cancer patients.
  • A2AR antagonists demonstrate efficacy as monotherapy and in combination regimens.

Conclusions:

  • Adenosine A2A receptor (A2AR) blockade is a promising strategy for cancer immunotherapy.
  • Further research is needed to identify predictive biomarkers for patient selection.
  • Rational combination strategies involving A2AR antagonists require further investigation.
Keywords:
A2AR antagonistAdenosineAdenosine receptorTumor microenvironment

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