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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
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Research Progress of Exosomal microRNA in Cardiovascular Disease and Its Forensic Application Prospects

Xiao-Nan Ma1,2, Lu Lu3, Yan-Tong Huang1

  • 1Liaoning Province Key Laboratory of Forensic Bio-evidence Science, School of Forensic Medicine, China Medical University, Shenyang 110122, China.

Fa Yi Xue Za Zhi
|July 28, 2022
PubMed

Insights

Exosomal microRNAs (miRNAs) are key communicators in cardiovascular diseases. This review highlights their role in disease prediction, treatment, and forensic identification, offering new diagnostic insights.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Exosomal microRNAs (miRNAs) mediate intercellular communication via exosomes.
  • Cardiovascular diseases (CVDs) involve complex biological functions influenced by exosomal miRNAs.
  • Sudden cardiac death is a critical aspect of forensic medical identification.

Purpose of the Study:

  • To review the research progress on exosomal miRNAs in cardiovascular disease prediction, treatment, and prognosis.
  • To explore the application of exosomal miRNAs in forensic medical identification.

Main Methods:

  • Literature review of studies on exosomal miRNAs and cardiovascular diseases.
  • Analysis of exosomal miRNA roles in disease development and outcomes.
  • Discussion of forensic applications.

Main Results:

  • Exosomal miRNAs play a significant role in the occurrence and progression of cardiovascular diseases.
  • Exosomal miRNAs show potential for predicting disease risk, guiding treatment, and determining prognosis.
  • Forensic identification of cardiovascular events may benefit from exosomal miRNA analysis.

Conclusions:

  • Exosomal miRNAs are crucial biomarkers for cardiovascular health and disease.
  • Further research into exosomal miRNAs can advance cardiovascular medicine and forensic science.
Keywords:
cardiovascular diseaseexosomeforensic pathologymicroRNA (miRNA)reviewsudden cardiac death

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