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Published on: June 2, 2014
Headache at the chronic stage of cerebral venous thrombosis
Alexandre Souza Bossoni1, Mario Fernando Prieto Peres2, Claudia da Costa Leite3
1Neurology Clinical Division, Hospital das Clínicas/São Paulo University, São Paulo - SP, Brazil.
Insights
Post-cerebral venous thrombosis headache (PCH) affects over half of patients, often resembling tension-type or migraine headaches. A history of primary headaches may increase the risk of developing PCH.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroscience
Background:
- Headache is a common symptom of cerebral venous thrombosis (CVT).
- Limited data exists on the frequency, characteristics, and predictors of post-cerebral venous thrombosis headache (PCH).
Purpose of the Study:
- To determine the frequency and characteristics of PCH.
- To identify potential predictors of PCH.
Main Methods:
- A cross-sectional study of 100 cerebral venous thrombosis survivors.
- Patients were interviewed 6 months to 5 years post-diagnosis.
- Clinical, imaging, and prior headache history data were compared between patients with and without PCH.
Main Results:
- PCH was present in 59% of patients.
- Common PCH phenotypes included tension-type-like (52.6%) and migraine-like (27.1%) headaches.
- A history of primary headache before CVT was a significant predictor of PCH (OR: 6.4).
Conclusions:
- PCH is a common condition affecting over half of CVT survivors.
- Prior headache history may be a risk factor for PCH.
- Further research is needed to confirm findings and explore prevention/treatment strategies.
Background:
Headache is the most frequent symptom of cerebral venous thrombosis (CVT) but there is limited information about the frequency and phenotype of headache, weeks to months after cerebral venous thrombosis (post-cerebral venous thrombosis headache, PCH).
Objective:
To assess the frequency, characteristics and predictors of PCH.
Methods:
In this cross-sectional study, the frequency and characteristics of PCH were assessed in cerebral venous thrombosis survivors. Patients were interviewed between six months and five years after the cerebral venous thrombosis diagnosis. Clinical and imaging characteristics at the time of cerebral venous thrombosis diagnosis, as well as history of headache prior to cerebral venous thrombosis were compared in subjects with (GroupPCH) and without PCH (Groupcontrol).
Results:
Subjects (n = 100; 82% women) were assessed, on average, at 1.1 ± 1.6 years of follow-up. PCH was present in 59% of the patients, phenotypes of tension-type-like headache were present in 31/59 (52.6%) and of migraine-like headache in 16/59 (27.1%). History of primary headache prior to cerebral venous thrombosis was significantly more common (OR: 6.4; 95% CI: 1.7-36.3) in GroupPCH (33.9%) than in Groupcontrol (7.3%).
Conclusion:
PCH was present in more than half of the patients. History of prior headache may be a risk factor for PCH. Prospective studies are required to confirm these findings and determine mechanisms, as well as interventions for prevention and treatment of PCH.
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