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Published on: April 21, 2015
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Interleukin 15 in murine models of colitis
Alicia Molina Kautzman1, Jeanne Masunga Faida Mobulakani1, Gisela Marrero Cofino2
1Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Anatomical Record (Hoboken, N.J. : 2007)
|July 28, 2022
Summary
Interleukin-15 (IL-15) plays a role in inflammatory bowel diseases (IBD). This study investigated the contribution of IL-15 to pathological intestinal inflammation using three experimental colitis models.
Area of Science:
- Immunology
- Gastroenterology
- Molecular Biology
Background:
- Inflammatory bowel diseases (IBD) involve chronic intestinal inflammation of unknown cause.
- Genetic and environmental factors contribute to IBD pathogenesis.
- The pro-inflammatory cytokine Interleukin-15 (IL-15) is implicated in IBD, with increased expression in inflamed IBD mucosa.
Purpose of the Study:
- To investigate the role of IL-15 in the pathogenesis of experimental colitis.
- To determine the contribution of IL-15 to pathological intestinal inflammation in pre-clinical models.
Main Methods:
- Utilized three well-characterized models of experimental colitis.
- Assessed the role of IL-15 in the development and maintenance of intestinal inflammation.
Main Results:
- IL-15 expression is elevated in the inflamed intestinal mucosa of IBD patients.
- IL-15 contributes to the maintenance of specific cell populations within the intestinal mucosa.
- The study evaluated the specific contribution of IL-15 in established colitis models.
Conclusions:
- IL-15 is a significant factor in the pathological processes of experimental colitis.
- Further research into IL-15's role could reveal new therapeutic targets for IBD.
