Structure Class Encoding in Protein Dynamic Bioinformatics

Using recently developed methods for studying the bioinformatics of protein dynamics, we investigate differences in dynamic characteristics between the sequences of proteins that fall into different structural classes. It is shown that there is a clear differentiation of dynamic properties of sequences as a function of structural class. Taken together with previous results we have developed, the present work demonstrates that dynamic properties are associated with structural behavior in two ways. The determination as to whether a given sequence folds is governed by the long-length-scale organization of the sequence. If the sequence folds, the choice of architectural class is governed by short- and intermediate-length-scale organization.