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Updated: Sep 3, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson's disease
Baptiste Texier1, Morgane Prime1, Djamaa Atamena2
1Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY), Université Toulouse, CNRS, Inserm, UPS, Toulouse, France.
Abstract:
By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intracellular calcium fluxes, Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity. However, its expression and stability are strongly modified in response to cellular stresses, in particular upon altered oxidative conditions during neurodegeneration. Here, we report and discuss the abundant literature that has highlighted its contribution to the pathophysiology of Parkinson's disease, as well as its therapeutic and prognostic potential in this still incurable pathology.
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