HIV-related lymphomas
Emanuela Vaccher1, Annunziata Gloghini2, Antonino Carbone3
1Medical Oncology and Immune-related Tumours, Centro di Riferimento Oncologico (CRO) di Aviano IRCCS, National Cancer Institute, Aviano.
Purpose Of Review:
To summarize the recent evidence on the pathology, current standard of care and recent advances in the treatment of HIV-related lymphomas.
Recent Findings:
Lymphomas remain a major cause of morbidity and mortality in people living with HIV, even in the era of combination antiretroviral therapy (cART). However, treatment outcomes for these malignancies have improved in recent decades, due to full-dose chemotherapy, effective cART and supportive care. Recent advances include the identification of novel driving signaling pathways as promising molecular targets to improve lymphoma outcomes.
Summary:
Patients with HIV-related lymphomas who receive effective cART should be treated like the general population.
Related Concept Videos
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Sexually Transmitted Infections
Retrovirus Life Cycles


