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SARS-CoV2 Infection and Comorbidities, Role in Oncogenesis
Liudmila V Spirina1,2, Nadezhda V Masunova2, Vladimir N Masunov2,3
1Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 5 Koopertivny street, Tomsk, 634050, Russia.
Asian Pacific Journal of Cancer Prevention : APJCP
|July 28, 2022
Summary
Cancer patients face higher COVID-19 risks, and post-infection, cancer incidence may rise due to unknown mechanisms. Early anticancer therapy targeting metabolic changes improves COVID-19 treatment outcomes.
Area of Science:
- Oncology
- Infectious Diseases
- Metabolic Disorders
Background:
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection poses significant risks to cancer patients, increasing their susceptibility and risk of severe COVID-19.
- Emerging evidence suggests a potential long-term increase in global cancer incidence as a consequence of post-COVID-19 complications.
- The interplay between viral infections, oncogenesis, immunogenicity, and metabolic dysregulation is complex and not fully understood.
Purpose of the Study:
- To investigate the oncogenic impact of SARS-CoV-2 infection and its relationship with metabolic alterations.
- To explore the role of modified immunogenicity and metabolic features in COVID-19 pathogenesis and patient response.
- To evaluate the efficacy of preventive anticancer therapies that incorporate metabolic process considerations for patients with pre-existing conditions.
Main Methods:
- Analysis of molecular mechanisms underlying virus-induced transformation and oncogenesis.
- Investigation of metabolic pathway alterations in the context of COVID-19 infection.
- Development and assessment of a modified therapeutic algorithm for cancer patients with COVID-19.
Main Results:
- Cancer patients exhibit heightened vulnerability to SARS-CoV-2, leading to more severe COVID-19 outcomes.
- SARS-CoV-2 infection can influence oncogenesis through largely unknown molecular pathways.
- Modified immunogenicity and metabolic dysregulation are critical factors in COVID-19 pathogenesis and host response.
Conclusions:
- Preventive anticancer therapies that address metabolic changes may enhance patient response to anti-COVID-19 treatments compared to antiviral drugs alone.
- A tailored therapeutic approach can mitigate the risk of post-acute complications in patients with pre-existing conditions and prevent the onset of new chronic pathologies, including cancer.
- Understanding the intricate links between viral infections, cancer, and metabolism is crucial for developing effective treatment strategies.
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