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Smart Internal Bio-Glues.

Hengjie Zhang1, Jianhua Zhang1, Xu Peng2

  • 1College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 28, 2022
PubMed
Summary
This summary is machine-generated.

New smart bio-glues use near-infrared light for minimally invasive surgery. These advanced internal bio-glues offer improved tissue adhesion and wound healing for internal and external applications.

Keywords:
adhesionhemostasisinternal wound healingsmart bio-glues

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Nanotechnology

Background:

  • Development of internal bio-glues for minimally invasive surgery faces challenges in safety and deep tissue penetration.
  • Existing smart bio-glues often lack stimuli for internal surgical applications.

Purpose of the Study:

  • To develop novel smart internal bio-glues for minimally invasive surgery.
  • To create bio-glues responsive to near-infrared (NIR) light for enhanced deep tissue penetration and functionality.

Main Methods:

  • Integration of o-nitrobenzene modified biopolymers with up-conversion nanoparticles (UCNPs).
  • Utilizing near-infrared (NIR) light irradiation to trigger gelation and tissue adhesion.
  • Evaluation of biocompatibility, hemostatic performance, and wound healing acceleration.

Main Results:

  • Developed NIR light-responsive bio-glues capable of gelation and strong tissue adhesion under various conditions.
  • Demonstrated deeper tissue penetration ability compared to conventional methods.
  • Exhibited good biocompatibility, excellent hemostatic performance, and accelerated wound healing for both internal and external wounds.

Conclusions:

  • The novel NIR light-responsive bio-glues show significant promise for internal wound healing in minimally invasive surgery.
  • This technology offers a safe and effective solution for advanced surgical applications.
  • The developed bio-glues provide new opportunities for robust internal tissue adhesion and accelerated healing.