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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

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Sex differences in the relationship between age, performance, and BOLD signal variability during spatial context

Hongye Wang¹, Ford Burles¹, Sivaniya Subramaniapillai²

¹Department of Psychology, University of Calgary, Calgary, Alberta, Canada.

Neurobiology of Aging

|July 28, 2022

Summary

This summary is machine-generated.

Brain signal variability during memory tasks differs between men and women as they age. Women show increased variability linked to performance, while men

Keywords:

Aging BOLD signal variability Biological sex Context memory

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Last Updated: Sep 3, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

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Published on: May 7, 2014

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A Within-Subject Experimental Design using an Object Location Task in Rats

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Published on: May 6, 2021

Area of Science:

Neuroscience
Cognitive Psychology
Human Aging Research

Background:

The relationship between aging, memory, and brain activity may differ between sexes.
Previous studies indicate potential sex-specific patterns in age-related cognitive changes.

Purpose of the Study:

To investigate sex differences in the association between age, memory performance, and brain signal variability.
To examine how blood oxygen-level-dependent standard deviation (BOLD SD) patterns change with age and performance in men and women during memory tasks.

Main Methods:

Recruited 128 neurotypical adults (aged 19-76 years, 87 women).
Measured BOLD SD during easy and difficult spatial context memory encoding and retrieval tasks.
Analyzed sex-specific, age- and performance-associated BOLD SD patterns.

Main Results:

Behavioral analysis showed age-related memory retrieval decline but no sex differences.
Both sexes exhibited a negative correlation between BOLD SD and retrieval accuracy in memory regions.
Women displayed age-associated BOLD SD increases negatively linked to performance; men showed variable BOLD SD changes unrelated to performance.

Conclusions:

Significant sex differences exist in how brain signal variability relates to aging during demanding episodic memory tasks.
These findings highlight the importance of considering sex in neuroscientific research on memory and aging.