Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

2.0K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
2.0K
Inflammation01:38

Inflammation

54.9K
Overview
54.9K
Antibody Actions01:26

Antibody Actions

1.3K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.3K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

2.5K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
2.5K
Antimicrobial Proteins01:23

Antimicrobial Proteins

4.2K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A self-powered and reusable biocomputing security keypad lock system based on biofuel cells.

Chemistry (Weinheim an der Bergstrasse, Germany)·2010
Same author

Prevalence of nerve-vessel contact at cisternal segments of the oculomotor nerve in asymptomatic patients evaluated with magnetic resonance images.

Chinese medical journal·2010
Same author

Overexpression and characterization in Bacillus subtilis of a positionally nonspecific lipase from Proteus vulgaris.

Journal of industrial microbiology & biotechnology·2010
Same author

Strategies to minimize variability and bias associated with manual pipetting in ligand binding assays to assure data quality of protein therapeutic quantification.

Journal of pharmaceutical and biomedical analysis·2010
Same author

Medium- and long-chain triacylglycerols reduce body fat and blood triacylglycerols in hypertriacylglycerolemic, overweight but not obese, Chinese individuals.

Lipids·2010
Same author

[The clinical application of 320-slice Computed Tomography (CT) hepatic artery images in patients with liver transplantation].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2010
Same journal

Corrigendum to "Lipophilic recombinant-protein insertion endows lymphocytes with enhanced targeting-infiltration ability in EGFR positive cancer" [Cell. Immunol. 365 (2021) 104376].

Cellular immunology·2026
Same journal

Retraction notice to "Myeloid-derived suppressor cells accumulate in the liver site after sepsis to induce immunosuppression" Cellular Immunology 279 (2012) 12-20.

Cellular immunology·2026
Same journal

The uptake, intracellular trafficking and recycling of FcRn-blocking therapeutics in human endothelial cells in vitro.

Cellular immunology·2026
Same journal

Exosome-mediated immune modulation in rheumatoid arthritis and its role in synovial inflammation and autoimmune amplification.

Cellular immunology·2026
Same journal

Persistent CD4<sup>+</sup> T cell hyporesponsiveness during recovery from prolonged symptomatic SARS-CoV-2 infection.

Cellular immunology·2026
Same journal

Deficit in blood MAIT cells, altered cytokines and T cell dynamics in patients with coronary artery disease.

Cellular immunology·2026
See all related articles

Related Experiment Video

Updated: Sep 3, 2025

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments
07:28

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

62.5K

Neutrophils, functions beyond host defense.

Jin Wang1, Jing Wang1

  • 1Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cellular Immunology
|July 28, 2022
PubMed
Summary
This summary is machine-generated.

Neutrophils, key immune cells, exhibit surprising complexity and diverse roles beyond simple phagocytosis. Recent research highlights their plasticity and communication with other immune cells in health and disease.

Keywords:
GranulopoiesisHeterogeneityNeutrophilSingle-cell sequencing

More Related Videos

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
10:05

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

15.4K
ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
09:44

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

Published on: January 3, 2025

604

Related Experiment Videos

Last Updated: Sep 3, 2025

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments
07:28

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

62.5K
Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
10:05

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

15.4K
ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
09:44

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

Published on: January 3, 2025

604

Area of Science:

  • Immunology
  • Cell Biology
  • Hematology

Background:

  • Neutrophils are the most abundant white blood cells, crucial for innate immunity.
  • Traditionally viewed as simple phagocytes, their roles are increasingly recognized as more complex.
  • Recent technological advancements have enabled deeper investigation into neutrophil behavior.

Purpose of the Study:

  • To review the evolving understanding of neutrophil heterogeneity and function.
  • To explore the multifaceted roles of neutrophils in homeostasis and inflammation.
  • To discuss neutrophil interactions with other immune cells.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of data from cutting-edge techniques like single-cell sequencing.
  • Synthesis of findings on neutrophil plasticity and communication.

Main Results:

  • Neutrophils display significant heterogeneity and plasticity under various conditions.
  • Neutrophils perform functions beyond phagocytosis, including immune modulation.
  • Direct and indirect communication between neutrophils and other immune cells is well-established.

Conclusions:

  • Neutrophil identities are more versatile than previously understood.
  • Neutrophil interplay with innate and adaptive immunocytes is critical for immune responses.
  • Further research continues to uncover novel neutrophil functions and interactions.