Three-dimensional MoS₂-graphene aerogel nanocomposites for electrochemical sensing of quercetin

A facile and novel electrochemical sensing platform is reported for quercetin determination with MoS₂ nanoflowers-3D graphene aerogel (3D MoS₂-GA) nanocomposite as signal amplified material. The 3D MoS₂-GA nanocomposite was synthesized through a two-step hydrothermal method, in which MoS₂ nanoflowers were prepared in advance. Characterizations of 3D MoS₂-GA were performed by scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The 3D MoS₂-GA-modified glassy carbon electrode (3D MoS₂-GA/GCE) was used to investigate the electrochemical behaviors of quercetin with electrochemical parameters calculated, reaction mechanism discussed, and experimental conditions optimized. Notably, the redox peak current densities of quercetin on 3D MoS₂-GA/GCE raised 5.14 and 6.40 times compared with those on a bare GCE. Furthermore, a novel electroanalytical approach was proposed for the sensitive determination of quercetin within the concentration range 0.01 ~ 5.0 μmol/L, accompanied by a low detection limit of 0.0026 μmol/L (at a working potential of 0.38 V vs. Ag/AgCl). The recovery for practical sample analysis ranges from 97.0 to 105%, and the relative standard deviation is less than 4.2%. This established method shows reliable performance in determination of quercetin in tablets and urine samples.