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Myricetin: targeting signaling networks in cancer and its implication in chemotherapy

Zeeshan Javed1, Khushbukhat Khan2, Jesús Herrera-Bravo3,4

  • 1Office of Research Innovation and Commercialization, Lahore Garrison University, Lahore, Pakistan.

Cancer Cell International
|July 28, 2022
PubMed

Insights

Myricetin, a natural flavonoid, shows promise as an anti-cancer agent with fewer side effects. This review explores its potential, particularly in nano-delivery systems for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer therapeutics face challenges like therapy resistance and adverse side effects.
  • Molecular oncology research has improved understanding of tumor heterogeneity and cell biology.
  • There is a growing need for effective cancer treatments with reduced toxicity.

Purpose of the Study:

  • To review the anti-cancer properties of myricetin, a natural flavonoid.
  • To explore myricetin's role in regulating cancer progression, invasion, and metastasis.
  • To summarize current nano-delivery platforms for myricetin in cancer treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on myricetin in cancer.
  • Analysis of molecular mechanisms underlying myricetin's anti-cancer effects.
  • Investigation of available nano-formulations for myricetin delivery.

Main Results:

  • Myricetin exhibits significant anti-cancer, anti-oxidant, and anti-inflammatory properties.
  • Myricetin influences key signaling pathways involved in cancer development.
  • Limited data exists on myricetin-based nano-delivery systems for cancer therapy.

Conclusions:

  • Myricetin holds potential as a less toxic and highly effective anti-cancer therapeutic.
  • Further research into myricetin nano-formulations is crucial for clinical application.
  • Myricetin-based therapies could offer a promising avenue for cancer treatment.
Keywords:
ApoptosisCancerCell cycleMyricetinNano-deliverySignaling networks

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