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Updated: Sep 3, 2025

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Outcome prediction for hypothermic patients in cardiac arrest
Mathieu Pasquier1, Olivier Hugli2, Nicolas Hall2
1Department of Emergency Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Mathieu.Pasquier@chuv.ch.
Abstract:
The 5A score predicts in-hospital mortality of patients suffering from accidental hypothermia, including those not in cardiac arrest. The HOPE score was specifically developed to predict survival for the subgroup of hypothermic patients in cardiac considered for extracorporeal life support rewarming. The C-statistic in the external validation study of the HOPE score was 0.825 (95% CI: 0.753-0.897), confirming its excellent discrimination. In addition, its good calibration allows for a reliable interpretation of the corresponding survival probability after rewarming. The HOPE score should be used for predicting outcome and selecting hypothermic patients in cardiac arrest for rewarming.
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