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Updated: Sep 3, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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The Function of FoxK Transcription Factors in Diseases

Mujun Yu1, Haozhen Yu2, Nan Mu3

  • 1School of Life Sciences, Yan'an University, Yan'an, China.

Frontiers in Physiology
|July 29, 2022
PubMed

Insights

Forkhead box K1 and K2 (FoxK1/2) transcription factors regulate diseases. This review systematically analyzes their distinct roles in disease pathogenesis, offering insights for therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Disease Mechanisms

Background:

  • Forkhead box (FOX) transcription factors are vital regulators in numerous diseases.
  • FoxK1 and FoxK2, specific FOX family members, are increasingly researched.
  • While exhibiting functional overlap, FoxK1 and FoxK2 possess distinct regulatory functions in physiological and disease contexts.

Purpose of the Study:

  • To conduct a comprehensive literature review on the similarities and differences in the roles of FoxK1/2 in disease.
  • To elucidate the biological functions and mechanisms of FoxK1/2.
  • To provide a foundation for understanding disease pathogenesis, prognosis prediction, and identifying novel therapeutic targets.

Main Methods:

  • Systematic literature review.
  • Analysis of existing research on FoxK1/2 function in various diseases.
  • Comparative analysis of FoxK1 and FoxK2 roles.

Main Results:

  • FoxK1 and FoxK2, despite functional overlap, exhibit distinct roles in disease regulation.
  • Evidence suggests differential involvement in various physiological and pathological processes.
  • A comprehensive understanding of their unique contributions is emerging.

Conclusions:

  • Understanding the distinct functions of FoxK1/2 is crucial for deciphering disease mechanisms.
  • This knowledge can aid in predicting disease prognosis.
  • FoxK1/2 represent potential targets for novel therapeutic strategies.
Keywords:
FOXK1FOXK2autophagycancermetabolic disease

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