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Theranostic Options for Radioiodine-Refractory Differentiated Thyroid Carcinoma: Recent Advances, Challenges, and

Swayamjeet Satapathy1, Chandrasekhar Bal1

  • 1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Frontiers in Endocrinology
|July 29, 2022
PubMed

Insights

Novel theranostic approaches, including radiolabeled integrin binders and fibroblast activation protein (FAP)-inhibitors, show promise for treating radioiodine-refractory differentiated thyroid cancer (RAIR-DTC). These strategies may offer improved outcomes compared to current tyrosine kinase inhibitors.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) is challenging to treat, often leading to poor patient outcomes.
  • Current treatments like tyrosine kinase inhibitors have significant side effects impacting quality of life.

Purpose of the Study:

  • To review novel theranostic strategies for RAIR-DTC.
  • To highlight recent advancements, challenges, and future directions in this field.

Main Methods:

  • Review of current literature on targeted theranostic agents.
  • Focus on radiolabeled integrin binders and fibroblast activation protein (FAP)-inhibitors.

Main Results:

  • Theranostic approaches offer a promising alternative to conventional therapies.
  • Radiolabeled integrin binders and FAP-inhibitors demonstrate potential for targeted treatment.

Conclusions:

  • Novel theranostic strategies are emerging as a significant advancement in managing RAIR-DTC.
  • Further research is needed to overcome existing challenges and optimize these treatments.
Keywords:
FAPIRAIR-DTCRGDintegrin bindersradioiodine-refractory differentiated thyroid cancertheranostic

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